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ORGENTEC公司成立于1988年，公司總部位于德國(guó)的美因茨市。主要產(chǎn)品包括ABC試劑盒，各種標(biāo)記二抗，Western試劑盒，蛋白分子量Marker，核抽提物等。ORGENTEC致力為免疫檢測(cè)用戶(hù)提供更多的產(chǎn)品與服務(wù)。
Anti-MCV?
The Anti-MCV? ELISA by ORGENTEC detects autoantibodies against mutated citrullinated vimentin (MCV) and is an efficient and reliable serological test for rheumatoid arthritis. Anti-MCV? detects the disease at a very early stage, even in patients who test negative for rheumatoid factor, and to some degree even before the appearance of specific clinical symptoms.
Autoantibodies against mutated citrullinated vimentin are highly specific and extremely sensitive markers for rheumatoid arthritis (specificity 97 %, sensitivity > 82 %). Anti-MCV? autoantibodies are an indicator of advanced injury to the joints and aggressive progression of the disease. In contrast to the detection of antibodies against synthetic cyclic citrullinated peptides, changes in the anti-MCV concentration correspond to changes of clinical parameters. As well as allowing for an unambiguous diagnosis, the Anti-MCV? ELISA thus also makes it possible to monitor therapeutic progress.
For point-of-care diagnosis, rheumachec? provides a rapid blood test that detects both anti-MCV autoantibodies and rheumatoid factor.
| Tests | 12 x 8 determinations | |
| Productnumber | ORG 548 | |
| Calculation | quantitative | |
| Range | 0-1000 U/ml | |
| Cut-off | 20 U/ml | |
| Sensitivity | 1 U/ml | |
| Calibration | arbitrary | |
| Substrate | TMB | |
| Antigens | MCV (mutated citrullinated vimentin) | |
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